abstract：:soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that f...

journal_title：Disease markers

authors： Thunø M,Macho B,Eugen-Olsen J

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. This association has been identified by amyloid deposits and neurofibrillary tangles in the brains of patients with neurodegenerative diseases. ...

journal_title：Disease markers

authors： Gallegos-Arreola MP,Figuera LE,Ortiz GG,Jiménez-Gil FJ,Ramírez-Vega J,Ruíz-Sandoval JL,Puebla-Pérez AM,Troyo-Sanroman R,García-Ortiz JE,Sanchez-Corona J,Zúñiga-González GM

更新日期：2009-01-01 00:00:00

abstract：:Chromosomal aneuploidy consists the leading cause of fetal death in our species. Around 50% of spontaneous abortions until 15 weeks of gestational age are chromosomally aneuploid, with trisomies accounting for 50% of the abnormal abortions. Trisomy 21 is the most common chromosome abnormality in liveborns and is usual...

journal_title：Disease markers

authors： Kokotas H,Grigoriadou M,Mikkelsen M,Giannoulia-Karantana A,Petersen MB

更新日期：2009-01-01 00:00:00

abstract：:Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic charac...

journal_title：Disease markers

authors： Pine SR,Marshall B,Varticovski L

更新日期：2008-01-01 00:00:00

abstract：:Alcohol abuse is one of the most common risk factor for chronic pancreatitis, but the underlying pathophysiological mechanisms remain unclear. The aim of this study was to identify genes that contribute to susceptibility or resistance for alcoholic chronic pancreatitis by screening the whole genome. Sixty-five patient...

journal_title：Disease markers

authors： Kitahara K,Kawa S,Katsuyama Y,Umemura T,Ozaki Y,Takayama M,Arakura N,Ota M

更新日期：2008-01-01 00:00:00

abstract：:Familial Amyloidotic Polyneuropathy (FAP) is a disorder characterized by the extracellular deposition of fibrillar Transthyretin (TTR) amyloid, with a special involvement of the peripheral nerve. Several extracellular matrix proteins have been found elevated in tissues from FAP patients, namely metalloproteinase-9 (MM...

journal_title：Disease markers

authors： Cardoso I,Brito M,Saraiva MJ

更新日期：2008-01-01 00:00:00

abstract：:In this work we explored the role of the 3'UTR of the MECP2 gene in patients with clinical diagnosis of RTT and mental retardation; focusing on regions of the 3'UTR with almost 100% conservation at the nucleotide level among mouse and human. By mutation scanning (DOVAM-S technique) the MECP2 3'UTR of a total of 66 aff...

journal_title：Disease markers

authors： Santos M,Yan J,Temudo T,Oliveira G,Vieira JP,Fen J,Sommer S,Maciel P

更新日期：2008-01-01 00:00:00

abstract：:Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined ...

journal_title：Disease markers

authors： Keller MD,Kanter EM,Lieber CA,Majumder SK,Hutchings J,Ellis DL,Beaven RB,Stone N,Mahadevan-Jansen A

更新日期：2008-01-01 00:00:00

abstract：:We evaluated the occurrence of mutations in P53, K-RAS, COX-2, expression of COX-2 and hTERT and relations among clinicopathological signs. P53 mutations were identified in 34.4% of tumours, the majority of them occurring in SCC (squamous cell carcinoma, 55.6%). K-RAS was mutated in 12.2% of NSCLC tumours, the majorit...

journal_title：Disease markers

authors： Strazisar M,Rott T,Glavac D

更新日期：2008-01-01 00:00:00

abstract：:IgA nephropathy (IgAN) is a kidney disease with a varying renal prognosis. Recently, many studies have demonstrated that renal alpha-smooth muscle actin (alpha-SMA) and transforming growth factor (TGF-beta1) expression, as well interstitial mast cell infiltrates could represent a prognostic marker in several renal dis...

journal_title：Disease markers

authors： Silva GE,Costa RS,Ravinal RC,dos Reis MA,Dantas M,Coimbra TM

更新日期：2008-01-01 00:00:00

abstract：:Inflammatory diseases are accompanied by numerous changes at the site of inflammation as well as many systemic physiological and biochemical changes. In the past two decades more and more attention is being paid to changes in glycosylation and in this review we describe some of the changes found on main serum proteins...

journal_title：Disease markers

authors： Gornik O,Lauc G

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Soluble vascular endothelial growth factor (VEGF) is a promising biomarker in monitoring rheumatoid arthritis (RA), but studies of pre-analytical and biologic variability are few. METHODS:VEGF was measured by ELISA methods in serum and plasma from healthy persons and RA patients. Pre-analytical factors were...

journal_title：Disease markers

authors： Hetland ML,Christensen IJ,Lottenburger T,Johansen JS,Svendsen MN,Hørslev-Petersen K,Nielsen L,Nielsen HJ

更新日期：2008-01-01 00:00:00

abstract：:IGF2 is the first gene discovered to be imprinted and expressed exclusively from the paternal allele in both human and mouse. IGF2 is also the first imprinted gene displaying loss of imprinting (LOI) or aberrant imprinting in human cancers. Evidently, LOI or reactivation of the maternal allele of IGF2 is associated wi...

journal_title：Disease markers

authors： Cui H

更新日期：2007-01-01 00:00:00

abstract：:Human papillomaviruses (HPV) infect cutaneous and mucosal epithelia and induce benign and malignant lesions. Non-melanoma skin cancer (NMSC), encompassing basal cell carcinoma and squamous cell carcinoma (SCC), is the most frequent cancer in the Caucasian population, and the incidence has increased dramatically worldw...

journal_title：Disease markers

authors： Nindl I,Gottschling M,Stockfleth E

更新日期：2007-01-01 00:00:00

abstract：:Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer developmen...

journal_title：Disease markers

authors： Mok SC,Kwong J,Welch WR,Samimi G,Ozbun L,Bonome T,Birrer MJ,Berkowitz RS,Wong KK

更新日期：2007-01-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and ...

journal_title：Disease markers

authors： Giovannoni G

更新日期：2006-01-01 00:00:00

abstract：:Over the last few years the interest in diagnostic markers for specific diseases has increased continuously. It is expected that they not only improve a patient's medical treatment but also contribute to accelerating the process of drug development. This demand for new biomarkers is caused by a lack of specific and se...

journal_title：Disease markers

authors： Schrader M,Selle H

更新日期：2006-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common viral respiratory pathogen during infancy world wide. It induces innate and adaptive immune response in host cells. The toll like receptor 4 (TLR4)/CD14 complex is particularly important for the initiation of an innate immune response to RSV. Thus we were interested...

journal_title：Disease markers

authors： Puthothu B,Forster J,Heinzmann A,Krueger M

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:specific polymorphisms of genes regulating intracellular redox balance and oxidative stress are related to atherogenesis. Some studies have identified a relationship between progression of atherosclerosis and C242T mutation in CYBA gene coding for p22phox, a subunit of the NADH/NADPH oxidase system. DESIGN:...

journal_title：Disease markers

authors： Nasti S,Spallarossa P,Altieri P,Garibaldi S,Fabbi P,Polito L,Bacino L,Brunelli M,Brunelli C,Barsotti A,Ghigliotti G

更新日期：2006-01-01 00:00:00

abstract：:Antibodies against myelin oligodendrocyte antigens have been found in the immunoreactive brain lesions of Multiple Sclerosis (MS) patients. Recently it has been proposed that these antibodies can be used as a prognostic marker in the course of disease. However, the serum levels of these autoantibodies during different...

journal_title：Disease markers

authors： Angelucci F,Mirabella M,Frisullo G,Caggiula M,Tonali PA,Batocchi AP

更新日期：2005-01-01 00:00:00

abstract：:The genetic variation at the Apolipoprotein E locus (APOE) is an important determinant of plasma lipids and has been implicated in various human pathological conditions. The objective of the present study was to estimate the distribution of APOE alleles in five Venezuelan communities: two Amerindian tribes (Bari and Y...

journal_title：Disease markers

authors： Fernández-Mestre MT,Yehirobi C,Montagnani S,Balbas O,Layrisse Z

更新日期：2005-01-01 00:00:00

abstract：:Apolipoprotein E (apoE) plays an important role in lipid metabolism. Its epsilon4 allele has been consistently associated with lipoprotein disorders but its connection to myocardial infarction (MI) is controversial. Because epsilon4 frequency decreases with age we thought that the contradictory results in different st...

journal_title：Disease markers

authors： Garcés C,Maicas C,Grande R,Benavente M,Viturro E,Cano B,López D,de Oya M

更新日期：2005-01-01 00:00:00

abstract：:Heart disease is the leading cause of mortality and morbidity in the world. As such, biomarkers are needed for the diagnosis, prognosis, therapeutic monitoring and risk stratification of acute injury (acute myocardial infarction (AMI)) and chronic disease (heart failure). The procedure for biomarker development involv...

journal_title：Disease markers

authors： Stanley BA,Gundry RL,Cotter RJ,Van Eyk JE

更新日期：2004-01-01 00:00:00

abstract：:The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spon...

journal_title：Disease markers

authors： Oguz FS,Ocal L,Diler AS,Ozkul H,Asicioglu F,Kasapoglu E,Bozkurt G,Konice M,Carin M

更新日期：2004-01-01 00:00:00

abstract：:Microsatellite instability (MSI) analysis is becoming more and more important to detect sporadic primary tumors of the MSI phenotype as well as in helping to determine Hereditary Non-Polyposis Colorectal Cancer (HNPCC) cases. After some years of conflicting data due to the absence of consensus markers for the MSI phen...

journal_title：Disease markers

authors： Buhard O,Suraweera N,Lectard A,Duval A,Hamelin R

更新日期：2004-01-01 00:00:00

abstract：:The atomic force microscope (AFM) is emerging as a powerful tool in cell biology. Originally developed for high-resolution imaging purposes, the AFM also has unique capabilities as a nano-indenter to probe the dynamic viscoelastic material properties of living cells in culture. In particular, AFM elastography combines...

journal_title：Disease markers

authors： Costa KD

更新日期：2003-01-01 00:00:00

abstract：:The discovery that PSA exists in serum in both free and complexed forms led to development of immunoassays specific for different PSA forms. This helped in measuring free PSA in the presence of PSA-ACT (PSA-alpha antichymotrypsin), hence it was possible to calculate the percent free PSA or free to total PSA ratio, mea...

journal_title：Disease markers

authors： Thakur V,Singh PP,Talwar M,Mukherjee U

更新日期：2003-01-01 00:00:00

abstract：:Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e....

journal_title：Disease markers

authors： Feleppa EJ,Alam SK,Deng CX

更新日期：2002-01-01 00:00:00

abstract：:Alterations of the retinoblastoma (Rb) gene have been described in several human neoplasms and recently, it has been suggested that these alterations may play a role in the development of endometrial carcinomas. Paraffin sections from 31 cases of normal endometrium (16 proliferative, 15 secretory), 35 hyperplastic les...

journal_title：Disease markers

authors： Ioachim EE,Goussia AC,Kitsiou EG,Charalabopoulos K,Mermiga E,Stefanaki S

更新日期：2002-01-01 00:00:00

abstract：:Recent experiments have shown that when specific biomolecular interactions are confined to one surface of a microcantilever beam, changes in intermolecular nanomechanical forces provide sufficient differential torque to bend the cantilever beam. This has been used to detect single base pair mismatches during DNA hybri...

journal_title：Disease markers

authors： Majumdar A

更新日期：2002-01-01 00:00:00

abstract：:Biomarker measurements now support key decisions throughout the drug development process, from lead optimization to regulatory approvals. They are essential for documenting exposure-response relationships, specificity and potency toward the molecular target, untoward effects, and therapeutic applications. In a broader...

journal_title：Disease markers

authors： Swanson BN

更新日期：2002-01-01 00:00:00

abstract：:Tumor markers and antigens are normally highly expressed in malignant tissue, but not in the surrounding normal tissue. Serial Analysis of Gene Expression (SAGE) is a technology that counts mRNA transcripts and can be used to find those genes most highly induced in malignant tissues. SAGE produces a comprehensive prof...

journal_title：Disease markers

authors： Riggins GJ

更新日期：2001-01-01 00:00:00

abstract：:Chronic infection with the hepatitis B virus (HBV) is a known risk factor in the development of human hepatocellular carcinoma (HCC). The HBV-encoded X protein, HBx, has been investigated for properties that may explain its cancer cofactor role in transgenic mouse lines. We discuss here recent data showing that HBx is...

journal_title：Disease markers

authors： Madden CR,Slagle BL

更新日期：2001-01-01 00:00:00

abstract：:This study was undertaken to assess the biochemical changes induced in chronic schistosomiasis and/or chronic HCV, as well as to pinpoint the most significant parameters which could be used as dependable indices for the differentiation of single and coupled infections with or without liver cirrhosis. The selected pati...

journal_title：Disease markers

authors： Fahim FA,Esmat AY,Hassan GK,Abdel-Bary A

更新日期：2000-01-01 00:00:00

abstract：:The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 2...

journal_title：Disease markers

authors： Bottini N,Gloria-Bottini F,Lucarini N,Ronchetti PG,Fontana L

更新日期：2000-01-01 00:00:00

abstract：:We have previously identified an allele of the human SP-A2 gene that occurs with greater frequency in an RDS population [12]. Because of the importance of SP-A in normal lung function and its newly emerging role in innate host defense and regulation of inflammatory processes, we wish to better characterize genotypes o...

journal_title：Disease markers

authors： DiAngelo S,Lin Z,Wang G,Phillips S,Ramet M,Luo J,Floros J

更新日期：1999-12-01 00:00:00

abstract：:Increasingly women at high risk of breast cancer are opting for prophylactic surgery to reduce their risks. Data from 10 European centres that offer a risk counselling and screening service to women at risk show different approaches to the option of preventive surgery, although most centres adhere to a protocol includ...

journal_title：Disease markers

authors： Evans DG,Anderson E,Lalloo F,Vasen H,Beckmann M,Eccles D,Hodgson S,Møller P,Chang-Claude J,Morrison P,Stoppa-Lyonnet D,Steel M,Haites N

更新日期：1999-10-01 00:00:00

abstract：:The terminal portion of the pol gene and the entire env gene of the human endogenous retrovirus ERV3 was screened for polymorphic nucleotides. For this purpose fragments amplified from the desired regions of ERV3 were subjected to single strand conformational analysis (SSCP analysis). Using this approach, we detected ...

journal_title：Disease markers

authors： Rasmussen HB,Clausen J

更新日期：1998-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection prevalence was determined in 34 hepatocellular carcinoma (HCC) patients with underlying liver cirrhosis. Serum alfa-fetoprotein level was found to be more than 1000 ng/ml (3153 +/- 1451) in those patients. Anti-HCV antibodies were detected in 84% of patients sera negative for hepatiti...

journal_title：Disease markers

authors： Mabrouk GM

更新日期：1997-11-01 00:00:00

abstract：:The human papilloma virus (HPV) associated with hyperplastic epithelium in an oral denture fibroma was examined by southern blot hybridization. Extracted DNA was hybridized with full length linear HPV type 2a, 6b, 11, 16, 18, 31 and 33 DNAs as a mixed probe only under low stringent conditions. The hybridized bands dig...

journal_title：Disease markers

authors： Yamaguchi T,Shindoh M,Amemiya A,Notani K,Fukuda H,Sakaoka H,Inoue M,Fujinaga K

更新日期：1997-04-01 00:00:00